Now and again I get a rather "warm" hive- not evil, just to testy for me to want to mess with. Once I am sure it is a genetic issue (same reaction no matter what I do and, most important, chasing behavior) I simply squash the Queen. I let them raise a new one. If, in a couple months and a couple brood cycles later the hive is still not to my liking...El Squasho again. I have never had a 3rd generation Queen be as bad as her Grandmother. Infact, usually the new Queen produces good, calm bees, same as the rest in the apiary. I always assume there are more good genetics than bad floating around.
I am not that quick to buy new Queens, I have never noticed them to be any better than the ones my own hives produce.
I buy new Queens simply for new blood. This year it was Cordovans- lost most to a awfull SHB attack but the ones that have hung in there sure are pretty bees.