if it can happen it will at times, Had double deep cell build a few years ago, 2 cell frames in it, 70 of 90 cells took, 2 days before they hatched, found a marked queen in the cell builder and she destroyed all cells, I only mark queens that are laying in after her mating flight, she left her nuc and was found in the cell builder, it was about 20 feet away from the cell builder, lesson learned, when a cell builder is made, use queen excluder under bottom deep.