I imagine that a 1/2 depth would work, but mediums seem to be a better compromise. We call that an "extra shallow". It would be 4 11/16". But that leaves a very small area of comb up and down. The frames are 4 7/16" or so. The actual comb is only about 3 7/16" or so high.
I run all eight frame mediums. (6 5/8" deep boxes), which weigh, full of honey, about 45 to 48 pounds.