Holly spines probably won't phase cattle (if that's what you were thinking); they have thick skin. I don't remember if it's poisonous to them.
Also if you'll be in the area in sandals, hand weeding, or mulching with grass clippings from there, you may want to avoid spiny plants.
Says the person who planted about 75 feet of Oregon grape along a fence in a suburban backyard. The Oregon grape did keep humans from climbing over the fence.
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