I agree with Finsky, two frames are more than you need. I run 1 frame of drone comb per box. And I would not place it in the middle of the brood nest, I place mine in position 3 or 8 on the outer fringe of the brood nest. When you take out the capped frame, put it in your freezer. This will kill all the mites (and drones) and then scratch the cappings open and give it back to the hive and they will clean it out and the queen will lay it up again for the next round! :D
I use this method in conjunction with screened bottom boards, and food grade miniral oil soaked paper towels which the bees tear up and remove thereby getting the oil all over them which increases grooming behavior. These are my IPM methods and this year I will be starting some bees on natural sized cells as well. Good luck! :D